INTERACTION PROFILE-BASED PROTEIN CLASSIFICATION OF DEATH DOMAIN

Interaction profile-based protein classification of death domain

Abstract Background The increasing number of protein sequences and 3D structure obtained from genomic initiatives is leading many of us to focus on proteomics, and to dedicate our experimental and computational efforts on the creation and analysis of information derived from 3D structure.In particular, the high-throughput generation of protein-prot

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G-Quadruplexes at Telomeres: Friend or Foe?

Telomeres are DNA-protein complexes that cap and protect the ends of linear razor blade chromosomes.In almost all species, telomeric DNA has a G/C strand bias, and the short tandem repeats of the G-rich strand have the capacity to form into secondary structures in vitro, such as four-stranded G-quadruplexes.This has long prompted speculation that G

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